Sandra Bullock appears naked on Chelsea Handler's new chat show
She tells her: "You have a responsibility to be a respectable talk show host. This comes directly from Oprah's mouth to my ear, to my mouth, out of my mouth, into your ear, down your body, out your vagina, up my vagina and out my ass.
"The overall theme of this message is that you are a huge disappointment. Just because your the only person on late-night television who has tiny little lady bits does not give you a free pass.
"You have a responsibility to be a role model to young girls. And you need to lay off the booze."
Sandra also lays into Chelsea - who was once linked to rapper 50 Cent - for sleeping with her guests.
She says: "Stop sleeping with your guests! Stop it! It's beneath you. That is why I have not done your show. I do not want to sleep with you."
Chelsea replies by saying: "I don't sleep with that many any more - just some of the rappers."
When Sandra later appeared on the show out of character, Chelsea revealed that while she was completely nude, the Oscar winning star had chosen to subtly cover up her modesty.
She explained: "I was the only one who was really naked... Sandy's like, 'You can put a thong on and pasties'."
The show also saw Jennifer Aniston guest with Chelsea.
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